Seed Funding Opportunity
The Conte Center@UCI is soliciting applications for 3-5 grants of up to $30,000 each for innovative research projects focusing on how early-life experiences influence the brain and may thus contribute to vulnerability to mental illness. Full details here
Junior Researcher Annabel K. Short, Ph.D., and PI Tallie Z. Baram, MD, Ph.D. publish major review
A major new review from Annabel K. Short, Ph.D. and our PI, Tallie Z. Baram, MD, Ph.D., in Nature Reviews Neurology. A critical assessment of human literature on early-life adversity and vulnerability to cognitive problems. 200 refs and new ideas...Read the review here
Junior Researcher, Jessica L. Bolton, PhD, receives an NIMH K99/R00 Pathway to Independence Grant.
Conte Center@UCI Junior Researcher, Jessica Bolton, PhD, receives an NIMH K99/R00 Pathway to Independence Grant. The project title is "Defining the role of Microglia in the Synaptic Rewiring of the Hypothalamus by Early Life Adversity". This is a very prestigious and competitive award. Congratulations, Jessica!
Conte Center@UCI awarded five-year, $15 million Silvio O. Conte Grant.
The National Institute of Mental Health has awarded Dr. Tallie Z. Baram of the University of California, Irvine a five-year, $15 million Silvio O. Conte Center grant. The funding will allow her interdisciplinary team to continue studying how unpredictable parental and environmental signals influence an infant's vulnerability later in life to cognitive and emotional problems, such as risky behaviors, addiction, and post-traumatic stress disorder. Read the full story
In Finland, too, unpredictable maternal signals to the infant impact cognitive development!
A collaborative study between the Conte Center@UCI and the FinnBrain Institute in Turku, Finland shows remarkably similar effects of patterns of maternal signals on infant emotional regulation.
Davis EP, Korja R, Karlsson L, Glynn LM, Sandman CA, Vegetabile B, Kataja EL, Nolvi S, Sinerva E, Pelto J, Karlsson H, Stern HS, and Baram TZ. Across continents and demographics, unpredictable maternal signals are associated with children's cognitive function. 2019. EBioMedicine (in press)
The paper, now in press in EBioMedicine, demonstrates the universal importance of Conte Center discoveries. Elysia Davis, the lead author, notes: "Maternal unpredictability, that we term high entropy, is equally influential in kids in Finland and in California. Everything else was different about these populations. This is strong proof that patterns of maternal care/signals should be considered when assessing the early-life factors that modulate cognitive and emotional health, as well as vulnerability to mental illness.
Good News About a Breakthrough Conte Center Publication
The manuscript describing the QUIC (Questionnaire of Unpredictability In Childhood), has been accepted to Neuropsychopharmacology, the flagship journal of the American College of Neuropsychopharmacology. The paper enables researchers and practitioners working with infants, children, and adults to employ measures of unpredictability and fragmentation of early-life environment in clinical and study contexts.
The Conte Center is happy to share the paper and the methodologies with interested investigators throughout the world.
Kudos to Prof. Laura Glynn, the lead author of this important study.
Jessica L. Bolton, PhD receives NARSAD Young Investigator Award
Conte Center Postdoctoral fellow Jessica L. Bolton has been selected to receive the NARSAD Young Investigator Grant. Sponsored by the Brain & Behavior Research Foundation, this grant is prestigious amongst post-doctorates and young assistant professors in mental health research. This award will provide Dr. Bolton up to $35,000 per year for two years with a total of $70,000 to continue her research proposal, “Developmental Programming of Microglia-specific Functional and Transcriptomic Changes by Early-Life Adversity.”
New Center publication in Neuropsychopharmacology suggests that fragmentation and unpredictable parental signals may be relevant to smartphone use.
Cellphone/smartphone use is now constant and ubiquitous: Over 95% of millennials and 85% of Gen-X individuals own a smartphone...Read the full article
Conte Center Team Honored with ICTS Team Science Award
The Institute for Clinical and Translational Science has named Conte Center @ UCI the recipient of its 2018 Robert Newcomb Interdisciplinary Team Science Award. The award was created to “highlight and honor individuals who have played a formative role in bringing together teams of researchers from diverse, trans-, multi-, and interdisciplinary backgrounds in studies and projects that have advanced biomedical and clinical research” according to the center’s website. The award was presented at The 10th Annual ICTS Awards Dinner “People Who Make A Difference in Human Health”.
Conte Center Director receives American Academy of Neurology’s highest award
Dr. Tallie Z. Baram received the prestigious 2018 Cotzias Award during the American Academy of Neurology‘s 70th annual meeting, held in April 2018, in Los Angeles. Established in 1978, the Cotzias Lecture and Award are named for George C. Cotzias, MD, who together with colleagues developed L-Dopa treatment, the most commonly used intervention for Parkinson’s disease.
Dr. Baram delivered the lecture, “How Early-Life Experiences Sculpt Your Brain,” at the meeting’s Presidential Plenary Session on Sunday, April 22. Her groundbreaking research examines how such experiences, specifically stress or seizures, influence the function of brain cells, essentially by re-programming them. This influences how they assemble into precise brain circuits, which affects development and also vulnerability or resilience to mental illness.
Read the full article at UC Irvine Health News.
New Conte Center Publication in Proceedings of the National Academy of Sciences
Memory function of children seem to be worse if maternal care patterns were unpredictable. In adolescent rats, receiving fragmented and unpredictable maternal care early in life directly worsened memory.
Using both observations of human children and direct manipulation of maternal care in rodents enabled Conte Center investigators led by Profs. Elysia Davis and Tallie Z. Baram to conclude that brain development is sensitive to patterns of maternal-derived signals. Specifically, unpredictable and fragmented patterns of maternal signals may not permit optimal development of brain machinery that underlies cognitive functions.
These findings are highly important in today’s world where maternal interactions with her child might be disrupted and fragmented by numerous distractions.
Impaired ability to experience pleasure (anhedonia) can be reversed in adults!
Impaired ability to experience pleasure (anhedonia) resulting from fragmented/unpredictable early-life experiences can be reversed in adults! A paper by postdoctoral researcher Jessica Bolton and the UCI Conte Center team in the prominent journal Biological Psychiatry shows
Megan Curran receives 2017 Graduate Student Award
Conte Center MD/PhD graduate student Megan Curran received the 2017 Renée Harwick Advanced Graduate Student Award sponsored by the UCI Center for the Neurobiology of Learning and Memory. The Renée Harwick Advanced Graduate Student Award is funded by an endowed gift by Dr. Renée Harwick to recognize a graduate student who shows outstanding scientific promise and to support the completion of the student’s Ph.D. thesis.
2016 Neurobiology of Stress Workshop
The 2016 Neurobiology of Stress Workshop, sponsored in part by the Conte Center @ UCI, was held in sunny Southern California, had close to 200 participants and was a great success. The next workshop is bound for Banff/Calgary, Canada in June 2018. To learn more about the 2018 Workshop, contact co-organizers Matthew Hill or Jaideep Bains. To be added to the workshop distribution list, please send an email to email@example.com